Antioxidants, Free Full-Text

Por um escritor misterioso

Descrição

Age-related macular degeneration (AMD) is a complex, progressive degenerative retinal disease. Retinal pigment epithelial (RPE) cells play an important role in the immune defense of the eye and their dysfunction leads to the progressive irreversible degeneration of photoreceptors. Genetic factors, chronic inflammation, and oxidative stress have been implicated in AMD pathogenesis. Oxidative stress causes RPE injury, resulting in a chronic inflammatory response and cell death. The Y402H polymorphism in the complement factor H (CFH) protein is an important risk factor for AMD. However, the functional significance of CFH Y402H polymorphism remains unclear. In the present study, we investigated the role of CFH in the pro-inflammatory response using an in vitro model of oxidative stress in the RPE with the at-risk CFH Y402H variant. ARPE-19 cells with the at-risk CFH Y402H variant were highly susceptible to damage caused by oxidative stress, with increased levels of inflammatory mediators and pro-apoptotic factors that lead to cell death. Pretreatment of the ARPE-19 cell cultures with exogenous CFH prior to the induction of oxidative stress prevented damage and cell death. This protective effect may be related to the negative regulation of pro-inflammatory cytokines. CFH contributes to cell homeostasis and is required to modulate the pro-inflammatory cytokine response under oxidative stress in the ARPE-19 cells with the at-risk CFH Y402H variant.
Antioxidants, Free Full-Text
Oxygen, Free Full-Text
Antioxidants, Free Full-Text
Vitamin C: An Antioxidant Agent
Antioxidants, Free Full-Text
The antioxidant paradox - The Lancet
Antioxidants, Free Full-Text
Antioxidant properties of Milk and dairy products: a comprehensive
Antioxidants, Free Full-Text
Antioxidant Mechanism of Betaine without Free Radical Scavenging
Antioxidants, Free Full-Text
Generic Peak Performance High Altitude Organic Coffee. Fair Trade
Antioxidants, Free Full-Text
1 free radicals full by Transtellar Publications - Issuu
Antioxidants, Free Full-Text
Chicken Invaders 9 Free Download By Zohaib Soft - Colaboratory
Antioxidants, Free Full-Text
Antioxidants in human health and disease : Free Download, Borrow
de por adulto (o preço varia de acordo com o tamanho do grupo)